High-dose intravenous azathioprine pulse treatment in refractory Wegener's granulomatosis
نویسندگان
چکیده
منابع مشابه
High-dose intravenous azathioprine pulse treatment in refractory Wegener's granulomatosis.
SIR, in Wegener’s granulomatosis (WG) standard therapy with cyclophosphamide (CYC) is limited by treatment-associated shortand long-term morbidity and mortality as well as insufficient response in about 10% of all cases [1]. Several therapeutic regimes have been used for refractory disease with varied results, including monoclonal antibodies to TNF[2] and different surface markers of T-cells (C...
متن کاملENT manifestations of Wegeners granulomatosis.
Wegeners granulomatosis is a necrotizing granulomatous vasculitis with multisystemic involvement. We present two cases of Wegener's presenting with otological manifestations as the first symptom. These symptoms are subtle and diagnosis may be easily overlooked. Hence a high index of suspicion is required. Early diagnosis and treatment goes a long way in improving the outcomes and in preventing ...
متن کاملHigh-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis
BACKGROUND Regulatory T (Treg) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and Treg cell frequency, du...
متن کاملHigh-dose intravenous immunoglobulin treatment increases regulatory T cells in patients with eosinophilic granulomatosis with polyangiitis.
OBJECTIVE We studied the effects of intravenous immunoglobulin (IVIG) treatment on clinical symptoms and regulatory T (Treg) cell frequency in patients with eosinophilic granulomatosis with polyangiitis (EGPA). METHODS Twenty-two EGPA patients with severe mononeuritis multiplex or cardiac dysfunction received IVIG therapy combined with conventional therapy (corticosteroid, immunosuppressants,...
متن کاملNeutrophil chemotaxis in Wegeners granulomatosis and idiopathic pulmonary fibrosis
Background: The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in Wegeners granulomatosis (WG), implicate the neutrophil as a key effector cell. Previous studies have reported elevated neutrophil counts in the lung although the determinants of neutrophil chemotaxis in the WG lung are unknown. Methods: BALF cell counts, myeloperoxidase (MPO) and chemokines were measured in 27 patient...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2004
ISSN: 1460-2172
DOI: 10.1093/rheumatology/keh300